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notch pathway activity signature array  (Qiagen)


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    Structured Review

    Qiagen notch pathway activity signature array
    Adult T-cell leukemia (ATL) cells have a high <t>notch</t> <t>pathway</t> <t>activity</t> score. ( A ) Gene <t>array</t> analysis of Notch pathway activity <t>signature</t> genes in control, healthy peripheral blood mononuclear cells (PBMCs), two ATL lines (Jurkat, T-ALL and Nalm20, B-ALL), and three ATL lines (MT1, ATLT, and ATL25). Expression is normalized to control PBMCs and is color-coded to represent expression levels, as stated in . ( B ) Notch pathway activity score generated from array data and Qiagen pathway analysis. PBMCs served as a control, with a score of 0.0. ATL and ALL cell scores are in red and represent an elevation compared to PBMCs. p -values are indicated. ( C ) Graphs representing the Log10 normalized gene expression of Notch pathway genes of ATL cells (MT1, ATLT, and ALT25) compared to the Log10 normalized gene expression in PBMCs. Graphs are generated using Qiagen software. ( D ) Real-time PCR analysis of Notch targets in Jurkat, MT1, and ATL25. GAPDH served as a control. Results are from at least two distinct cDNA preparations, from at least two different experiments and real-time PCR runs. Cells were treated with 1 µM GSI for 48 h. Fold change is compared to cells treated with DMSO control. Significant decreases are indicated in pale green with p -values of at least > 0.05. ( E ) Venn diagram representing common GSI-sensitive targets among Jurkat (yellow), MT1 (red), and ATL25 (blue).
    Notch Pathway Activity Signature Array, supplied by Qiagen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/notch pathway activity signature array/product/Qiagen
    Average 90 stars, based on 1 article reviews
    notch pathway activity signature array - by Bioz Stars, 2026-02
    90/100 stars

    Images

    1) Product Images from "Increased H19 /miR-675 Expression in Adult T-Cell Leukemia Is Associated with a Unique Notch Signature Pathway"

    Article Title: Increased H19 /miR-675 Expression in Adult T-Cell Leukemia Is Associated with a Unique Notch Signature Pathway

    Journal: International Journal of Molecular Sciences

    doi: 10.3390/ijms25105130

    Adult T-cell leukemia (ATL) cells have a high notch pathway activity score. ( A ) Gene array analysis of Notch pathway activity signature genes in control, healthy peripheral blood mononuclear cells (PBMCs), two ATL lines (Jurkat, T-ALL and Nalm20, B-ALL), and three ATL lines (MT1, ATLT, and ATL25). Expression is normalized to control PBMCs and is color-coded to represent expression levels, as stated in . ( B ) Notch pathway activity score generated from array data and Qiagen pathway analysis. PBMCs served as a control, with a score of 0.0. ATL and ALL cell scores are in red and represent an elevation compared to PBMCs. p -values are indicated. ( C ) Graphs representing the Log10 normalized gene expression of Notch pathway genes of ATL cells (MT1, ATLT, and ALT25) compared to the Log10 normalized gene expression in PBMCs. Graphs are generated using Qiagen software. ( D ) Real-time PCR analysis of Notch targets in Jurkat, MT1, and ATL25. GAPDH served as a control. Results are from at least two distinct cDNA preparations, from at least two different experiments and real-time PCR runs. Cells were treated with 1 µM GSI for 48 h. Fold change is compared to cells treated with DMSO control. Significant decreases are indicated in pale green with p -values of at least > 0.05. ( E ) Venn diagram representing common GSI-sensitive targets among Jurkat (yellow), MT1 (red), and ATL25 (blue).
    Figure Legend Snippet: Adult T-cell leukemia (ATL) cells have a high notch pathway activity score. ( A ) Gene array analysis of Notch pathway activity signature genes in control, healthy peripheral blood mononuclear cells (PBMCs), two ATL lines (Jurkat, T-ALL and Nalm20, B-ALL), and three ATL lines (MT1, ATLT, and ATL25). Expression is normalized to control PBMCs and is color-coded to represent expression levels, as stated in . ( B ) Notch pathway activity score generated from array data and Qiagen pathway analysis. PBMCs served as a control, with a score of 0.0. ATL and ALL cell scores are in red and represent an elevation compared to PBMCs. p -values are indicated. ( C ) Graphs representing the Log10 normalized gene expression of Notch pathway genes of ATL cells (MT1, ATLT, and ALT25) compared to the Log10 normalized gene expression in PBMCs. Graphs are generated using Qiagen software. ( D ) Real-time PCR analysis of Notch targets in Jurkat, MT1, and ATL25. GAPDH served as a control. Results are from at least two distinct cDNA preparations, from at least two different experiments and real-time PCR runs. Cells were treated with 1 µM GSI for 48 h. Fold change is compared to cells treated with DMSO control. Significant decreases are indicated in pale green with p -values of at least > 0.05. ( E ) Venn diagram representing common GSI-sensitive targets among Jurkat (yellow), MT1 (red), and ATL25 (blue).

    Techniques Used: Activity Assay, Control, Expressing, Generated, Gene Expression, Software, Real-time Polymerase Chain Reaction



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    notch pathway activity signature array  (Qiagen)
    90
    Qiagen notch pathway activity signature array
    Adult T-cell leukemia (ATL) cells have a high <t>notch</t> <t>pathway</t> <t>activity</t> score. ( A ) Gene <t>array</t> analysis of Notch pathway activity <t>signature</t> genes in control, healthy peripheral blood mononuclear cells (PBMCs), two ATL lines (Jurkat, T-ALL and Nalm20, B-ALL), and three ATL lines (MT1, ATLT, and ATL25). Expression is normalized to control PBMCs and is color-coded to represent expression levels, as stated in . ( B ) Notch pathway activity score generated from array data and Qiagen pathway analysis. PBMCs served as a control, with a score of 0.0. ATL and ALL cell scores are in red and represent an elevation compared to PBMCs. p -values are indicated. ( C ) Graphs representing the Log10 normalized gene expression of Notch pathway genes of ATL cells (MT1, ATLT, and ALT25) compared to the Log10 normalized gene expression in PBMCs. Graphs are generated using Qiagen software. ( D ) Real-time PCR analysis of Notch targets in Jurkat, MT1, and ATL25. GAPDH served as a control. Results are from at least two distinct cDNA preparations, from at least two different experiments and real-time PCR runs. Cells were treated with 1 µM GSI for 48 h. Fold change is compared to cells treated with DMSO control. Significant decreases are indicated in pale green with p -values of at least > 0.05. ( E ) Venn diagram representing common GSI-sensitive targets among Jurkat (yellow), MT1 (red), and ATL25 (blue).
    Notch Pathway Activity Signature Array, supplied by Qiagen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/notch pathway activity signature array/product/Qiagen
    Average 90 stars, based on 1 article reviews
    notch pathway activity signature array - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Adult T-cell leukemia (ATL) cells have a high notch pathway activity score. ( A ) Gene array analysis of Notch pathway activity signature genes in control, healthy peripheral blood mononuclear cells (PBMCs), two ATL lines (Jurkat, T-ALL and Nalm20, B-ALL), and three ATL lines (MT1, ATLT, and ATL25). Expression is normalized to control PBMCs and is color-coded to represent expression levels, as stated in . ( B ) Notch pathway activity score generated from array data and Qiagen pathway analysis. PBMCs served as a control, with a score of 0.0. ATL and ALL cell scores are in red and represent an elevation compared to PBMCs. p -values are indicated. ( C ) Graphs representing the Log10 normalized gene expression of Notch pathway genes of ATL cells (MT1, ATLT, and ALT25) compared to the Log10 normalized gene expression in PBMCs. Graphs are generated using Qiagen software. ( D ) Real-time PCR analysis of Notch targets in Jurkat, MT1, and ATL25. GAPDH served as a control. Results are from at least two distinct cDNA preparations, from at least two different experiments and real-time PCR runs. Cells were treated with 1 µM GSI for 48 h. Fold change is compared to cells treated with DMSO control. Significant decreases are indicated in pale green with p -values of at least > 0.05. ( E ) Venn diagram representing common GSI-sensitive targets among Jurkat (yellow), MT1 (red), and ATL25 (blue).

    Journal: International Journal of Molecular Sciences

    Article Title: Increased H19 /miR-675 Expression in Adult T-Cell Leukemia Is Associated with a Unique Notch Signature Pathway

    doi: 10.3390/ijms25105130

    Figure Lengend Snippet: Adult T-cell leukemia (ATL) cells have a high notch pathway activity score. ( A ) Gene array analysis of Notch pathway activity signature genes in control, healthy peripheral blood mononuclear cells (PBMCs), two ATL lines (Jurkat, T-ALL and Nalm20, B-ALL), and three ATL lines (MT1, ATLT, and ATL25). Expression is normalized to control PBMCs and is color-coded to represent expression levels, as stated in . ( B ) Notch pathway activity score generated from array data and Qiagen pathway analysis. PBMCs served as a control, with a score of 0.0. ATL and ALL cell scores are in red and represent an elevation compared to PBMCs. p -values are indicated. ( C ) Graphs representing the Log10 normalized gene expression of Notch pathway genes of ATL cells (MT1, ATLT, and ALT25) compared to the Log10 normalized gene expression in PBMCs. Graphs are generated using Qiagen software. ( D ) Real-time PCR analysis of Notch targets in Jurkat, MT1, and ATL25. GAPDH served as a control. Results are from at least two distinct cDNA preparations, from at least two different experiments and real-time PCR runs. Cells were treated with 1 µM GSI for 48 h. Fold change is compared to cells treated with DMSO control. Significant decreases are indicated in pale green with p -values of at least > 0.05. ( E ) Venn diagram representing common GSI-sensitive targets among Jurkat (yellow), MT1 (red), and ATL25 (blue).

    Article Snippet: We performed a Notch pathway activity signature array developed by Qiagen that selects 16 experimentally derived Notch signature biomarker genes, which, along with classification algorithms, acquire a quantitative analysis to determine a Notch activity score for ATL and ALL cells.

    Techniques: Activity Assay, Control, Expressing, Generated, Gene Expression, Software, Real-time Polymerase Chain Reaction